Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries
نویسندگان
چکیده
منابع مشابه
Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries
The purpose of diversity-oriented synthesis is to drive the discovery of small molecules with previously unknown biological functions. Natural products necessarily populate biologically relevant chemical space, since they bind both their biosynthetic enzymes and their target macromolecules. Natural product families are, therefore, libraries of pre-validated, functionally diverse structures in w...
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1Laboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece 2Institute of Technology of Agricultural Products, Hellenic Agricultural Organization-DEMETER, 15310 Athens, Greece 3Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AD, UK 4School of Biomedical Scienc...
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ژورنال
عنوان ژورنال: Natural Product Reports
سال: 2008
ISSN: 0265-0568,1460-4752
DOI: 10.1039/b706296f